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The concentration of local anesthetic at the site of action is, therefore, determined by the speed of penetration into the endoneurium and the speed of diffusion into the capillary blood.
An ODT may have varying degrees of pregastric absorption and thus, the pharmacokinetic profiles will vary. 29 Therefore, the ODT will not be bioequivalent to the conventional oral dosage form. For example, ODT formulations of selegiline, apomorphine, and buspirone have significantly different pharmacokinetic profiles compared with the same dose administered in a conventional dosage form31,32. |
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