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Depending on the condition, use is made of: thiazides, loop diuretics, aldosterone antagonists, and osmotic diuretics. Antihypertensive therapy. Diuretics have long been used as drugs of first choice for lowering elevated blood pressure (p. 312). Even at low dosage, they decrease peripheral resistance (without significantly reducing EFV) and thereby normalize blood pressure.
Combustion of tobacco generates approx. 4000 chemical compounds in detectable quantities. The xenobiotic burden on the smoker depends on a range of parameters, including tobacco quality, presence of a filter, rate and temperature of combustion, depth of inhalation, and duration of breath holding. Tobacco contains 0.2–5 % nicotine.

 

At the start of therapy, gout attacks may occur, but they can be prevented by concurrent administration of colchicine (0. 5–1. 5 mg/d). Uricosurics, such as probenecid, benzbromarone (100 mg/d), or sulfinpyrazone, promote renal excretion of uric acid. They saturate the organic acid transport system in the proximal renal tubules, making it unavailable for urate reabsorption.
Erythropoiesis is stimulated by the hormone erythropoietin (a glycoprotein), which is released from the kidneys when renal O2 tension declines. Given an adequate production of erythropoietin, a disturbance of erythropoiesis is due to two principal causes: 1. Cell multiplication is inhibited because DNA synthesis is insufficient.

 

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