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There are several types of opioid receptors, designated ?, ?, ?, that mediate the various opioid effects; all belong to the superfamily of G-proteincoupled receptors. Endogenous opioids are peptides that are cleaved from the precursors proenkephalin, pro-opiomelanocortin, and prodynorphin. All contain the amino acid sequence of the pentapeptides [Met]- or [Leu]-enkephalin (A).
Zafirlukast is a long-acting, selective, and potent leukotriene receptor (LTD4, LTE4) antagonist with anti-inflammatory/ antiallergic activity and efficacy in the maintenance therapy of chronic asthma. It is given both orally and by inhalation. The onset of action is slow (3 to 14 d). Protective effects against inhaled LTD4 last up to 12 to 24 h.

 

Because digestion of food in the intestinal tract is dispensable and only counterproductive, the propulsion of intestinal contents is slowed to the extent that peristalsis diminishes and sphincteric tonus increases. However, in order to increase nutrient supply to heart and musculature, glucose from the liver and free fatty acid from adipose tissue must be released into the blood.
Drugs that decrease the coagulability of blood, such as coumarins and heparin (A), are employed for the prophylaxis of thromboses. In addition, attempts are directed at inhibiting the aggregation of blood platelets, which are prominently involved in intra-arterial thrombogenesis (p. 148). For the therapy of thrombosis, drugs are used that dissolve the fibrin meshwork>fibrinolytics.

 

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