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As blood phosphate concentration diminishes, the tendency of calcium to precipitate as bone mineral decreases. By stimulating the formation of vit. D hormone, parathormone has an indirect effect on the enteral uptake of Ca2+ and phosphate. In parathormone deficiency, vitamin D can be used as a substitute that, unlike parathormone, is effective orally.
When sweat secretion is inhibited, the body loses the ability to dissipate metabolic heat by evaporation of sweat. There is a compensatory vasodilation in the skin allowing increased heat exchange through increased cutaneous blood flow. Decreased peristaltic activity of the intestines leads to constipation.

 

Peripheral effects concern the motility and tonus of gastrointestinal smooth muscle; segmentation is enhanced, but propulsive peristalsis is inhibited. The tonus of sphincter muscles is raised markedly. In this fashion, morphine elicits the picture of spastic constipation. The antidiarrheic effect is used therapeutically (loperamide).
The proteins are used as “viral enzymes” catalyzing viral multiplication (e. g. , DNA polymerase and thymidine kinase), as capsomers, or as coat components, or are incorporated into the host cell membrane. (5) Individual components are assembled into new virus particles (maturation). (6) Release of daughter viruses results in spread of virus inside and outside the organism.

 

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