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The most important adverse effects are due to hypersensitivity (incidence up to 5%), with manifestations ranging from skin eruptions to anaphylactic shock (in less than 0. 05% of patients). Known penicillin allergy is a contraindication for these drugs. Because of an increased risk of sensitization, penicillins must not be used locally.
It can be employed after oral ingestion of a toxin in order to hasten elimination and to reduce absorption of toxin from the gut. Castor oil is not indicated after the ingestion of lipophilic toxins likely to depend on bile acids for their absorption. 2. b Large Bowel Irritant Purgatives Anthraquinone derivatives are of plant origin.

 

Their action occurs within minutes and lasts for 4 to 6 h. If ?2-mimetics have to be used more frequently than three times a week, more severe disease is present. At this stage, management includes antiinflammatory drugs, such as “mast-cell stabilizers” (in children or juvenile patients) or else glucocorticoids.
Before the introduction of the better tolerated acyclovir, vidarabine played a major part in the treatment of herpes simplex encephalitis. Among virustatic antimetabolites, acyclovir (A) has both specificity of the highest degree and optimal tolerability. because it undergoes bioactivation only in infected cells, where it preferentially inhibits viral DNA synthesis.

 

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