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Although simple to perform, these binding assays pose the difficulty of correlating unequivocally the binding sites concerned with the pharmacological effect; this is particularly difficult when more than one population of binding sites is present.
Statistics also show that, on cessation of smoking, the increased risk of death from coronary infarction or other cardiovascular disease declines over 5–10 years almost to the level of non-smokers. Similarly, the risk of developing bronchial carcinoma is reduced. Abrupt cessation of regular smoking is not associated with severe physical withdrawal symptoms.

 

A membrane transporter actively accumulates iodide in thyroid cells; this is followed by oxidation to iodine, iodination of tyrosine residues in thyroglobulin, conjugation of two diiodotyrosine groups, and formation of T4 and T3 moieties. These reactions are catalyzed by thyroid peroxidase, which is localized in the apical border of the follicular cell membrane.
Concerning iodine-induced hyperthyroidism, see p. 244 (B). Antithyroid drugs inhibit thyroid function. Release of thyroid hormone (C) is preceded by a chain of events.

 

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