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Matching dosage of the oral antidiabetic and caloric intake follows the same principles as apply to insulin. Hypoglycemia is the most important unwanted effect. Enhancement of the hypoglycemic effect can result from drug interactions: displacement of antidiabetic drug from plasma protein-binding sites by sulfonamides or acetylsalicylic acid.
Tacrolimus, a macrolide, derives from a streptomyces species; pharmacologically it resembles cyclosporin A, but is more potent and efficacious. The monoclonal antibodies daclizumab and basiliximab bind to the ?- chain of the II-2 receptor of T-lymphocytes and thus prevent their activation, e. g. , during transplant rejection. III. Disruption of cell metabolism with inhibition of proliferation.

 

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