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Atropine may be given to prevent cardiac arrest resulting from vagal reflex activation, incident to anesthetic induction, gastric lavage, or endoscopic procedures. Scopolamine is effective in the prophylaxis of kinetosis (motion sickness, sea sickness; it is well absorbed transcutaneously.
For instances, morphine (p. 210), given in the appropriate dose, affords excellent pain relief by influencing nociceptive pathways in the CNS. In excessive doses, it inhibits the respiratory center and makes apnea imminent. The dose dependence of both effects can be graphed in the form of dose-response curves (DRC).

 

They offer the advantage that a drug depot is attached noninvasively to the body, enabling the drug to be administered in a manner similar to an infusion. Drugs amenable to this type of delivery must: (1) be capable of penetrating the cutaneous barrier; (2) be effective in very small doses (restricted capacity of reservoir); and (3) possess a wide therapeutic margin (dosage not adjustable).
CAH catalyzes CO2 hydration/ dehydration reactions: H+ + HCO3 –-H2CO3-H20 + CO2. The enzyme is used in tubule cells to generate H+, which is secreted into the tubular fluid in exchange for Na+. There, H+ captures HCO3 –, leading to formation of CO2 via the unstable carbonic acid. Membrane-permeable CO2 is taken up into the tubule cell and used to regenerate H+ and HCO3 –.

 

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