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Thus, 5-HT2A and 5-HT7 receptors on vascular smooth muscle cells mediate direct vasoconstriction and vasodilation, respectively. Vasodilation and lowering of blood pressure can also occur by several indirect mechanisms: 5- HT1A receptors mediate sympathoinhibition ( decrease in neurogenic vasoconstrictor tonus) both centrally and peripherally;
Triglyceride-rich VLDL particles are released into the blood and, like the chylomicrons, supply other tissues with fatty acids. Left behind are LDL particles that either return into the liver or supply extrahepatic tissues with cholesterol.

 

Misuse of laxatives. It is a widely held belief that at least one bowel movement per day is essential for health; yet three bowel evacuations per week are quite normal. The desire for frequent bowel emptying probably stems from the time-honored, albeit mistaken, notion that absorption of colon contents is harmful. Thus, purging has long been part of standard therapeutic practice.
Rhinitis. Nasal discharge could be prevented by parasympatholytics; however, other atropine–like effects (pp. 104ff) would have to be accepted. Therefore, parasympatholytics are hardly ever used, although a corresponding action is probably exploited in the case of H1 antihistamines, an ingredient of many cold remedies.

 

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