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Too rapid entry into the circulation would lead to unwanted systemic reactions such as: blockade of inhibitory CNS neurons, manifested by restlessness and seizures (countermeasure: injection of a benzodiazepine); general paralysis with respiratory arrest after higher concentrations.
Injection of solutions of low concentration will fail to produce an effect; however, too high concentrations must also be avoided because of the danger of intoxication resulting from too rapid systemic absorption into the blood. |
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