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Too rapid entry into the circulation would lead to unwanted systemic reactions such as: blockade of inhibitory CNS neurons, manifested by restlessness and seizures (countermeasure: injection of a benzodiazepine); general paralysis with respiratory arrest after higher concentrations.
The region of fusion surrounds each cell like a ring, so that neighboring cells are welded together in a continuous belt.

 

Injection of solutions of low concentration will fail to produce an effect; however, too high concentrations must also be avoided because of the danger of intoxication resulting from too rapid systemic absorption into the blood.
Disintegration test The time for disintegration of ODTs is generally less than one minute and actual disintegration time that patient can experience ranges from 5-30 seconds. The standard procedure of performing disintegration test for these dosage forms has several limitations and they are not suitable for the measurement of very short disintegration times.

 

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