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Furthermore, it promotes platelet aggregability, lowers fibrinolytic activity of blood, and enhances coagulability. The health risks of tobacco smoking are, however, attributable not only to nicotine, but also to various other ingredients of tobacco smoke, some of which possess demonstrable carcinogenic properties.
When an agonist and a competitive antagonist are present simultaneously, affinity and concentration of the two rivals will determine the relative amount of each that is bound. Thus, although the antagonist is present, increasing the concentration of the agonist can restore the full effect (C).

 

In the inner ear, sensory cells of the vestibular apparatus and Corti’s organ may be injured (ototoxicity, in part irreversible). Mycobacteria are responsible for two diseases: tuberculosis, mostly caused by M. tuberculosis, and leprosy due to M. leprae. The therapeutic principle applicable to both is combined treatment with two or more drugs.
Naturally susceptible bacterial strains can be transformed under the influence of antibacterial drugs into resistant ones (acquired resistance), when a random genetic alteration (mutation) gives rise to a resistant bacterium. Under the influence of the drug, the susceptible bacteria die off, whereas the mutant multiplies unimpeded.

 

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