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To fulfill these medical needs, pharmaceutical technologists have developed a novel oral dosage form known as Orally Disintegrating Tablets (ODTs) which disintegrate rapidly in saliva, usually in a matter of seconds, without the need to take it water.
Covalent bond. Two atoms enter a covalent bond if each donates an electron to a shared electron pair (cloud). This state is depicted in structural formulas by a dash. The covalent bond is “firm”, that is, not reversible or only poorly so. Few drugs are covalently bound to biological structures.

 

At a low concentration, the tobacco alkaloid nicotine acts as a ganglionic stimulant by causing a partial depolarization via activation of ganglionic cholinoceptors. A similar action is evident at diverse other neural sites, considered below in more detail. Autonomic ganglia. Ganglionic stimulation occurs in both the sympathetic and parasympathetic divisions of the autonomic nervous system.
Therapeutic use aims at replacement. Mostly, vit. D is given; in liver disease calcifediol may be indicated, in renal disease calcitriol. Effectiveness, as well as rate of onset and cessation of action, increase in the order vit. D. < 25-OH-vit. D < 1,25-di-OH-vit. D.

 

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