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Treatment of advanced disease requires the combined administration of antiparkinsonian agents. Epilepsy is a chronic brain disease of diverse etiology; it is characterized by recurrent paroxysmal episodes of uncontrolled excitation of brain neurons.
Therefore, receptor binding must not be implied until it can be shown that binding is saturable (saturability); the only substances bound are those possessing the same pharmacological mechanism of action (specificity); binding affinity of different substances is correlated with their pharmacological potency.

 

Vegetable fibers in the diet act in this manner. They consist of the indigestible plant cell walls containing homoglycans that are resistant to digestive enzymes, e. g. , cellulose (1 4?-linked glucose molecules vs. 1 4? glucoside bond in starch, p. 153). Bran, a grain milling waste product, and linseed (flaxseed) are both rich in cellulose.
Transcytotic activity entails transport of fluid or macromolecules from the blood into the interstitium and vice versa. Any solutes trapped in the fluid, including drugs, may traverse the blood-tissue barrier. In this form of transport, the physicochemical properties of drugs are of little importance.

 

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