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Dextran is a glucose polymer formed by bacteria and linked by a 1>6 instead of the typical 1>4 bond. Commercial solutions contain dextran of a mean molecular weight of 70 kDa (dextran 70) or 40 kDa (lower-molecularweight dextran, dextran 40). The chain length of single molecules, however, varies widely.
The responsible enzyme can be blocked by entacapone, allowing higher levels of L-dopa and dopamine to be achieved in corpus striatum. Anticholinergics. Antagonists at muscarinic cholinoceptors, such as benzatropine and biperiden (p. 106), suppress striatal cholinergic overactivity and thereby relieve rigidity and tremor; however, akinesia is not reversed or is even exacerbated. |
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