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The drugs principally used are thiazides (possibly combined with K+-sparing diuretics) and loop diuretics. Prophylaxis of renal failure. In circulatory failure (shock), e. g. , secondary to massive hemorrhage, renal production of urine may cease (anuria). By means of diuretics an attempt is made to maintain urinary flow. Use of either osmotic or loop diuretics is indicated.
The hypothalamic releasing hormones are peptides. They reach their target cells in the AH lobe by way of a portal vascular route consisting of two serially connected capillary beds. The first of these lies in the hypophyseal stalk, the second corresponds to the capillary bed of the AH lobe. Here, the hypothalamic hormones diffuse from the blood to their target cells, whose activity they control. |
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