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The therapeutic effect may result in part from a reaction with aldehydes, whereby polymerization of collagen molecules into fibrils is inhibited. Unwanted effects are: cutaneous damage (diminished resistance to mechanical stress with a tendency to form blisters), nephrotoxicity, bone marrow depression, and taste disturbances.
ACE, in turn, produces biologically active angiotensin II (ANG II) from angiotensin I (ANG I). ACE is a rather nonspecific peptidase that can cleave C-terminal dipeptides from various peptides (dipeptidyl carboxypeptidase). As “kininase II,” it contributes to the inactivation of kinins, such as bradykinin.

 

(3) they permit binding of heparin to its antidote, protamine (polycationic protein from salmon sperm). If protamine is given in heparin-induced bleeding, the effect of heparin is immediately reversed. For effective thromboprophylaxis, a low dose of 5000 IU is injected s. c. two to three times daily.
Sympathomimetics can be used systemically in certain types of hypotension and locally for nasal or conjunctival decongestion (pp. 324, 326) or as adjuncts in infiltration anesthesia (p. 206) for the purpose of delaying the removal of local anesthetic. With local use, underperfusion of the vasoconstricted area results in a lack of oxygen (A).

 

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