Drug Name Tetracycline

Dimercaprol (BAL, British Anti-Lewisite) was developed in World War II as an antidote against vesicant organic arsenicals (B). It is able to chelate various metal ions. Dimercaprol forms a liquid, rapidly decomposing substance that is given intramuscularly in an oily vehicle.
Changes in adrenergic function are complex. Inhibition of neuronal catecholamine reuptake gives rise to superimposed indirect sympathomimetic stimulation. Patients are supersensitive to catecholamines (e. g. , epinephrine in local anesthetic injections must be avoided). On the other hand, blockade of ?1-receptors may lead to orthostatic hypotension.

 

Interactions. Antacids inhibit iron absorption. Combination with ascorbic acid (Vitamin C), for protecting Fe2+ from oxidation to Fe3+, is theoretically sound, but practically is not needed. Parenteral administration of Fe3+ salts is indicated only when adequate oral replacement is not possible. There is a risk of overdosage with iron deposition in tissues (hemosiderosis).
The technologies that have been used by various researchers to prepare orally disintegrating dosage forms include: Freeze- Drying or Lyophilization, Molding, Direct Compression, Disintegrant addition, Sublimation, Spray Drying, Mass Extrusion, Cotton-candy process, NanoCrystalTM Technology, Oral films/wafers.