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They are mostly used in combination with thiazide diuretics, e. g. , hydrochlorothiazide, because the opposing effects on K+ excretion cancel each other, while the effects on secretion of NaCl complement each other. b) Aldosterone antagonists. The mineralocorticoid aldosterone promotes the reabsorption of Na+ (Cl– and H2O follow) in exchange for K+.
Thus, reaction velocity reaches a plateau at blood ethanol concentrations of about 0. 02 %, and the amount of drug eliminated per unit of time remains constant at concentrations above this level. A. Drugs are taken up into and eliminated from the body by various routes.

 

In instituting single-drug therapy (monotherapy), the following considerations apply: ?-blockers are of value in the treatment of juvenile hypertension with tachycardia and high cardiac output; however, in patients disposed to bronchospasm, even ?1-selective blockers are contraindicated.
The drug effect may, however, become unmasked at daytime when other sedating substances (e. g. , ethanol) are ingested and the patient shows an unusually pronounced response due to a synergistic interaction (impaired ability to concentrate or react).

 

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