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They are mostly used in combination with thiazide diuretics, e. g. , hydrochlorothiazide, because the opposing effects on K+ excretion cancel each other, while the effects on secretion of NaCl complement each other. b) Aldosterone antagonists. The mineralocorticoid aldosterone promotes the reabsorption of Na+ (Cl– and H2O follow) in exchange for K+.
In instituting single-drug therapy (monotherapy), the following considerations apply: ?-blockers are of value in the treatment of juvenile hypertension with tachycardia and high cardiac output; however, in patients disposed to bronchospasm, even ?1-selective blockers are contraindicated. |
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