Drug Name Tribulus

Long-term use is likely to cause changes mimicking the signs of Cushing’s syndrome (endogenous overproduction of cortisol). Sequelae of the anti-inflammatory action: lowered resistance to infection, delayed wound healing, impaired healing of peptic ulcers.
After ingestion of high doses (approx. 10 g), the glutathione reserves of the liver are depleted and the quinonimine reacts with constituents of liver cells. As a result, the cells are destroyed: liver necrosis. Liver damage can be avoided if the thiol group donor, N-acetylcysteine, is given intravenously within 6–8 h after ingestion of an excessive dose of acetaminophen.

 

This isoenzyme breaks down dopamine in the corpus striatum and can be selectively inhibited by selegiline. Inactivation of norepinephrine, epinephrine, and 5-HT via MAOA is unaffected.
Tolerance. With repeated administration of opioids, their CNS effects can lose intensity (increased tolerance). In the course of therapy, progressively larger doses are needed to achieve the same degree of pain relief.