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Unlike inhalational agents, most of these drugs affect consciousness only and are devoid of analgesic activity (exception: ketamine). The effect cannot be ascribed to nonselective binding to neuronal cell membranes, although this may hold for propofol. Most injectable anesthetics are characterized by a short duration of action.
Overproduction of lactic acid (lactate acidosis, lethality 50%) is a rare, potentially fatal reaction. Metformin is used in combination with sulfonylureas or by itself. It is contraindicated in renal insufficiency and should therefore be avoided in elderly patients. |
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