Drug Name Reglan

Two possible explanations are: (1) the conversion of spironolactone into and accumulation of the more slowly eliminated metabolite canrenone; (2) an inhibition of aldosterone-stimulated protein synthesis would become noticeable only if existing proteins had become nonfunctional and needed to be replaced by de novo synthesis.
Moreover, by interfering with the actions of mediator substances on inflammatory cells, it causes a more general inhibition of allergic inflammation. It is applied locally to: conjunctiva, nasal mucosa, bronchial tree (inhalation), intestinal mucosa (absorption almost nil with oral intake).

 

Metoclopramide is effective in nausea and vomiting of gastrointestinal origin (5-HT4-receptor agonism) and at high dosage also in chemotherapy- and radiation- induced sickness (low potency antagonism at 5-HT3- and D2-receptors).
Cardioacceleration Ipratropium is used in bradycardia and AV-block, respectively, to raise heart rate and to facilitate cardiac impulse conduction. As a quaternary substance, it does not penetrate into the brain, which greatly reduces the risk of CNS disturbances (see below). Relatively high oral doses are required because of an inefficient intestinal absorption.