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During repolarization, Ca2+ levels fall below the threshold for activation of the myofilaments (3 10–7 M), as the plasmalemmal binding sites regain their binding capacity; the SR pumps Ca2+ into its interior; and Ca2+ that entered the cytosol during systole is again extruded by plasmalemmal Ca2+-ATPases with expenditure of energy.
Decreased volume of saliva may slow the rate of disintegration/dissolution and decrease the bioavailability of the product. Although chewable tablets have been in the market for some time, they are not the same as the new ODTs. Patients for whom chewing is difficult or painful can use these new tablets easily. |
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