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Etomidate hardly affects the autonomic nervous system. Since it inhibits cortisol synthesis, it can be used in the treatment of adrenocortical overactivity (Cushing’s disease). Midazolam is a rapidly metabolized benzodiazepine (p. 228) that is used for induction of anesthesia.
This approach is based on the expectation that binding sites will retain their characteristic properties during cell homogenization. Provided that binding sites are freely accessible in the medium in which membrane fragments are suspended, drug concentration at the “site of action” would equal that in the medium. |
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