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Etomidate hardly affects the autonomic nervous system. Since it inhibits cortisol synthesis, it can be used in the treatment of adrenocortical overactivity (Cushing’s disease). Midazolam is a rapidly metabolized benzodiazepine (p. 228) that is used for induction of anesthesia.
The ability to chelate Ca2+ accounts for the propensity of tetracyclines to accumulate in growing teeth and bones. As a result, there occurs an irreversible yellowbrown discoloration of teeth and a reversible inhibition of bone growth. Because of these adverse effects, tetracycline should not be given after the second month of pregnancy and not prescribed to children aged 8 y and under.

 

This approach is based on the expectation that binding sites will retain their characteristic properties during cell homogenization. Provided that binding sites are freely accessible in the medium in which membrane fragments are suspended, drug concentration at the “site of action” would equal that in the medium.
Alternatively, the vesicle may fuse with the opposite cell membrane (cytopempsis).

 

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