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Many drugs exhibit a linear relationship between plasma concentration and dose within the therapeutic range (dose-linear kinetics; (A); note different scales on ordinate).
Consequently, the right t-RNAAA complex shifts to the left, allowing the next complex to be bound at the right. These individual steps are susceptible to inhibition by antibiotics of different groups. The examples shown originate primarily from Streptomyces bacteria, some of the aminoglycosides also being derived from Micromonospora bacteria.

 

In case this treatment fails (no effect within 30 min, administration of morphine, if needed in combination with an antiemetic to prevent morphine-induced vomiting, is indicated. If ECG signs of myocardial infarction are absent, the patient is stabilized by antianginal therapy (nitrates, ?- blockers) and given ASA and heparin.
The treatment of choice (after the cause of bleeding has been found and eliminated) consists of the oral administration of Fe2+ compounds, e.g., ferrous sulfate (daily dose 100 mg of iron equivalent to 300 mg of FeSO4, divided into multiple doses). Replenishing of iron stores may take several months.

 

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