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During this process, a protease contained within the polyprotein cleaves the latter into individual, functionally active proteins. I. Inhibitors of Reverse Transcriptase IA. Nucleoside agents These substances are analogues of thymine (azidothymidine, stavudine), adenine (didanosine), cytosine (lamivudine, zalcitabine), and guanine (carbovir, a metabolite of abacavir).
The sartans (candesartan, eprosartan, irbesartan, losartan, and valsartan) are AT1 antagonists that reliably lower high blood pressure. They do not inhibit degradation of kinins and cough is not a frequent side-effect. Bronchodilators. Narrowing of bronchioles raises airway resistance, e.g., in bronchial or bronchitic asthma.

 

Liberated norepinephrine reacts with adrenoceptors located postjunctionally on the membrane of effector cells or prejunctionally on the membrane of varicosities. Activation of presynaptic ?2-receptors inhibits norepinephrine release. By this negative feedback, release can be regulated.
Whether 5- HT antagonism accounts for its antihypertensive effect remains questionable, because ketanserin also blocks ?-adrenoceptors. Sumatriptan and other triptans are antimigraine drugs that possess agonist activity at 5-HT1 receptors of the B, D and F subtypes and may thereby alleviate this type of headache.

 

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