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With oral administration, dividing the total daily dose into several individual ones, e. g. , four, three, or two, offers a practical compromise. When the daily dose is given in several divided doses, the mean plasma level shows little fluctuation. In practice, it is found that a regimen of frequent regular drug ingestion is not well adhered to by patients.
Wound disinfection can be achieved with hydrogen peroxide (0. 3%–1% solution; short, foaming action on contact with blood and thus wound cleansing) or with potassium permanganate (0. 0015% solution, slightly astringent), as well as PVP iodine, chlorhexidine, and biguanidines.

 

Hepatic elimination obeys exponential kinetics because metabolizing enzymes operate in the quasilinear region of their concentration-activity curve; hence the amount of drug metabolized per unit of time diminishes with decreasing blood concentration.
Hygienic and surgical hand disinfection: The former is required after a suspected contamination, the latter before surgical procedures. Alcohols, mixtures of alcohols and phenols, cationic surfactants, or acids are available for this purpose. Admixture of other agents prolongs duration of action and reduces flammability.

 

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