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Risperidone (Risperdal) is a second generation[1] or atypical antipsychotic. It is used to treat schizophrenia , schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in people with autism. It is associated with significant weight gain and metabolic problems, as well as tardive dyskinesia and neuroleptic malignant syndrome.
Although stimulation of parasympathetic cardioinhibitory neurons would tend to lower heart rate, this response is overridden by the simultaneous stimulation of sympathetic cardioaccelerant neurons and the adrenal medulla. Stimulation of sympathetic nerves resulting in release of norepinephrine gives rise to vasoconstriction; peripheral resistance rises.

 

Parenteral or, alternatively, sublingual, intranasal, or transdermal administration is then required in order to bypass the liver. Irrespective of the route of administration, a portion of administered drug may be taken up into and transiently stored in lung tissue before entering the general circulation. This also constitutes presystemic elimination.
In the distal tubules (dT), NaCl and water are again jointly reabsorbed. At the end of the nephron, this process involves an aldosterone- controlled exchange of Na+ against K+ or H+. In the collecting tubule (C), vasopressin (antidiuretic hormone, ADH) increases the epithelial permeability for water, which is drawn into the hyperosmolar milieu of the renal medulla and thus retained in the body.

 

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