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Risperidone (Risperdal) is a second generation[1] or atypical antipsychotic. It is used to treat schizophrenia , schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in people with autism. It is associated with significant weight gain and metabolic problems, as well as tardive dyskinesia and neuroleptic malignant syndrome.
Parenteral or, alternatively, sublingual, intranasal, or transdermal administration is then required in order to bypass the liver. Irrespective of the route of administration, a portion of administered drug may be taken up into and transiently stored in lung tissue before entering the general circulation. This also constitutes presystemic elimination. |
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