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Because the newly formed reductase is inhibited, too, the hepatocyte must meet its cholesterol demand by uptake of LDL from the blood (B). Accordingly, the concentration of circulating LDL decreases, while its hepatic clearance from plasma increases. There is also a decreased likelihood of LDL being oxidized into its proatheroslerotic degradation product.
Doublestranded DNA is incorporated into the host genome with the help of viral integrase. Under control by viral DNA, viral replication can then be initiated, with synthesis of viral RNA and proteins (including enzymes such as reverse transcriptase and integrase, and structural proteins such as the matrix protein lining the inside of the viral envelope). |
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