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Myometrial stimulants. The neurohypophyseal hormone oxytocin is given parenterally (or by the nasal or buccal route) before, during, or after labor in order to prompt uterine contractions or to enhance them.
G?- GTP of the GS-protein stimulates adenylate cyclase, whereas G?-GTP of the Giprotein is inhibitory. The G-proteincoupled receptor family includes muscarinic cholinoceptors, adrenoceptors for norepinephrine and epinephrine, receptors for dopamine, histamine, serotonin, glutamate, GABA, morphine, prostaglandins, leukotrienes, and many other mediators and hormones.

 

All benzodiazepines exert their actions at specific receptors (p. 226). The choice between different agents is dictated by their speed, intensity, and duration of action. These, in turn, reflect physicochemical and pharmacokinetic properties. Individual benzodiazepines remain in the body for very different lengths of time and are chiefly eliminated through biotransformation.
In the axoplasm, L-tyrosine is converted via two intermediate steps to dopamine, which is taken up into the vesicles and there converted to norepinephrine by dopamine-?-hydroxylase. When stimulated electrically, the sympathetic nerve discharges the contents of part of its vesicles, including norepinephrine, into the extracellular space.

 

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