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Anti-inflammatory therapy is the more successful the less use is made of asneeded ?2-mimetic medication. Severe cases may, however, require an intensified bronchodilator treatment with systemic ?2-mimetics or theophylline (systemic use only; low therapeutic index; monitoring of plasma levels needed).
When the enzyme is inhibited, these reactions are slowed, so that less Na+, HCO3 – and water are reabsorbed from the fast-flowing tubular fluid. Loss of HCO3 – leads to acidosis. The diuretic effectiveness of CAH inhibitors decreases with prolonged use. CAH is also involved in the production of ocular aqueous humor.

 

The determination of plasma levels affords a comparison of different proprietary preparations containing the same drug in the same dosage. Identical plasma level time-curves of different manufacturers’ products with reference to a standard preparation indicate bioequivalence of the preparation under investigation with the standard.
The antihypertensive agents, reserpine (obsolete) and ?-methyldopa, deplete neuronal stores of the amine. A common adverse effect of dopamine antagonists or depletors is parkinsonism. Histamine (B).Histamine is stored in basophils and tissue mast cells.

 

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