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Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
When the drug is distributed faster than it is absorbed, the time course of the plasma level can be described in mathematically simplified form by the Bateman function (k1 and k2 represent the rate constants for absorption and elimination, respectively). B. The velocity of absorption depends on the route of administration. |
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