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Hence, these compounds are highly polar, poorly membrane permeable, and not absorbed enterally. Neomycin and paromomycin are given orally to eradicate intestinal bacteria (prior to bowel surgery or for reducing NH3 formation by gut bacteria in hepatic coma). Aminoglycosides for the treatment of serious infections must be injected (e. g. , gentamicin, tobramycin, amikacin, netilmicin, sisomycin).
Acetylcholine (ACh) is the transmitter at postganglionic synapses of parasympathetic nerve endings. It is highly concentrated in synaptic storage vesicles densely present in the axoplasm of the terminal. ACh is formed from choline and activated acetate (acetylcoenzyme A), a reaction catalyzed by the enzyme choline acetyltransferase.

 

An injectable solution must be free of infectious agents, pyrogens, or suspended matter. It should have the same osmotic pressure and pH as body fluids in order to avoid tissue damage at the site of injection. Solutions for injection are preserved in airtight glass or plastic sealed containers.
Unlike barbiturates, benzodiazepine derivatives administered orally lack a general anesthetic action; cerebral activity is not globally inhibited (respiratory paralysis is virtually impossible) and autonomic functions, such as blood pressure, heart rate, or body temperature, are unimpaired. Thus, benzodiazepines possess a therapeutic margin considerably wider than that of barbiturates.

 

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