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Clindamycin is a semisynthetic chloro analogue of lincomycin, which derives from a Streptomyces species. Taken orally, clindamycin is better absorbed than lincomycin, has greater antibacterial efficacy and is thus preferred. Both penetrate well into bone tissue.
Thyroid overactivity in Graves’ disease (A) results from formation of IgG antibodies that bind to and activate TSH receptors. Consequently, there is overproduction of hormone with cessation of TSH secretion. Graves’ disease can abate spontaneously after 1–2 y. Therefore, initial therapy consists of reversible suppression of thyroid activity by means of antithyroid drugs.

 

Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. In a bulk powder form, it appears as a white crystalline powder, and it is very slightly soluble in water and soluble in alcohol. It is commonly marketed under the trade name Diflucan or Trican (Pfizer).
With any of the high-efficacy opioid analgesics, overdosage is likely to result in respiratory paralysis (impaired sensitivity of medullary chemoreceptors to CO2). The maximally possible extent of respiratory depression is thought to be less in partial agonist/ antagonists at opioid receptors (pentazocine, nalbuphine).

 

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