Drug Name Nexium

The underlying causes are: most commonly, an atherosclerotic change of the vascular wall (coronary sclerosis with exertional angina); very infrequently, a spasmodic constriction of a morphologically healthy coronary artery (coronary spasm with angina at rest; variant angina); or more often, a coronary spasm occurring in an atherosclerotic vascular segment.
The drug of choice is nitroglycerin (NTG, 0. 8–2. 4 mg sublingually; onset of action within 1 to 2 min; duration of effect ~30 min). Isosorbide dinitrate (ISDN) can also be used (5–10 mg sublingually); compared with NTG, its action is somewhat delayed in onset but of longer duration.

 

Benzene, polycyclic aromatic compounds (e. g. , benzopyrene), and unsaturated cyclic carbohydrates can be converted by mono-oxygenases to epoxides, highly reactive electrophiles that are hepatotoxic and possibly carcinogenic. The second type of oxidative biotransformation comprises dealkylations.
In order to maintain body temperature at its physiological level, excess heat must be dissipated—the patients have a hot skin and are sweating. The hypothalamic temperature controller (B1) can be inactivated by neuroleptics (p. 236), without impairment of other centers. Thus, it is possible to lower a patient’s body temperature without activating counter-regulatory mechanisms.